Late p65 nuclear translocation in glioblastoma cells indicates non-canonical TLR4 signaling and activation of DNA repair genes

Late p65 nuclear translocation in glioblastoma cells indicates non-canonical TLR4 signaling and activation of DNA repair genes

Abstract Glioblastoma (GBM) is the most aggressive brain primary malignancy. Toll-like receptor 4 (TLR4) has a dual role in cell fate, promoting cell survival or death depending on the context. Here, we analyzed TLR4 expression in different grades of astrocytoma, and observed increased expression in...

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Bibliographic Details
Main Authors: Isabele F. Moretti, Antonio M. Lerario, Marina Trombetta-Lima, Paula R. Sola, Roseli da Silva Soares, Sueli M. Oba-Shinjo, Suely K. N. Marie
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79356-1

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https://doi.org/10.1038/s41598-020-79356-1

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