Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer.

Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer.

MUC16 is overexpressed in ovarian cancer and plays important roles in invasion and metastasis. Previously described monoclonal antibodies against cell surface expressed MUC16 recognize the N-terminal tandemly repeated epitopes present in cancer antigen 125 (CA125). MUC16 is cleaved at a specific loc...

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Bibliographic Details
Main Authors: Abhijit Aithal, Wade M Junker, Prakash Kshirsagar, Srustidhar Das, Sukhwinder Kaur, Catherine Orzechowski, Shailendra Kumar Gautam, Rahat Jahan, Yuri M Sheinin, Imayavaramban Lakshmanan, Moorthy P Ponnusamy, Surinder K Batra, Maneesh Jain
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5927449?pdf=render

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http://europepmc.org/articles/PMC5927449?pdf=render

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