Integral Membrane Protein 2A Is a Negative Regulator of Canonical and Non-Canonical Hedgehog Signalling

Integral Membrane Protein 2A Is a Negative Regulator of Canonical and Non-Canonical Hedgehog Signalling

The Hedgehog (Hh) receptor PTCH1 and the integral membrane protein 2A (ITM2A) inhibit autophagy by reducing autolysosome formation. In this study, we demonstrate that ITM2A physically interacts with PTCH1; however, the two proteins inhibit autophagic flux independently, since silencing of ITM2A did...

Full description

Bibliographic Details
Main Authors: Cintli C. Morales-Alcala, Ioanna Ch. Georgiou, Alex J. Timmis, Natalia A. Riobo-Del Galdo
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
hedgehog
patched1
ITM2A
GLI
autophagy
skeletal muscle
Online Access:https://www.mdpi.com/2073-4409/10/8/2003

Internet

https://www.mdpi.com/2073-4409/10/8/2003

Similar Items