Integral Membrane Protein 2A Is a Negative Regulator of Canonical and Non-Canonical Hedgehog Signalling
The Hedgehog (Hh) receptor PTCH1 and the integral membrane protein 2A (ITM2A) inhibit autophagy by reducing autolysosome formation. In this study, we demonstrate that ITM2A physically interacts with PTCH1; however, the two proteins inhibit autophagic flux independently, since silencing of ITM2A did...
Main Authors: | Cintli C. Morales-Alcala, Ioanna Ch. Georgiou, Alex J. Timmis, Natalia A. Riobo-Del Galdo |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/10/8/2003 |
Similar Items
-
Non-canonical Hedgehog signaling regulates spinal cord and muscle regeneration in Xenopus laevis larvae
by: Andrew M Hamilton, et al.
Published: (2021-05-01) -
Expression of Sonic Hedgehog and pathway components in the embryonic mouse head: anatomical relationships between regulators of positive and negative feedback
by: Crystal L. Sigulinsky, et al.
Published: (2021-08-01) -
Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened
by: Silvia Pietrobono, et al.
Published: (2019-06-01) -
Analyse des Hedgehog-Signalweges in Zellkulturen maligner Gliome
by: Braun, Stefanie Anett
Published: (2013) -
Non-Canonical Hh Signaling in Cancer—Current Understanding and Future Directions
by: Dongsheng Gu, et al.
Published: (2015-08-01)