Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells?
The functional avidity is determined by exposing T-cell populations in vitro to different amounts of cognate antigen. T-cells with high functional avidity respond to low antigen doses. This in vitro measure is thought to correlate well with the in vivo effector capacity of T-cells. We here present t...
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Online Access: | http://dx.doi.org/10.1155/2012/153863 |
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doaj-dbe16d1558184c83b3c4c36ccc1964ce2020-11-24T23:14:31ZengHindawi LimitedClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/153863153863Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells?Selena Viganò0Daniel T. Utzschneider1Matthieu Perreau2Giuseppe Pantaleo3Dietmar Zehn4Alexandre Harari5Divisions of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, SwitzerlandDivisions of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, SwitzerlandDivisions of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, SwitzerlandDivisions of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, SwitzerlandDivisions of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, SwitzerlandDivisions of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, SwitzerlandThe functional avidity is determined by exposing T-cell populations in vitro to different amounts of cognate antigen. T-cells with high functional avidity respond to low antigen doses. This in vitro measure is thought to correlate well with the in vivo effector capacity of T-cells. We here present the multifaceted factors determining and influencing the functional avidity of T-cells. We outline how changes in the functional avidity can occur over the course of an infection. This process, known as avidity maturation, can occur despite the fact that T-cells express a fixed TCR. Furthermore, examples are provided illustrating the importance of generating T-cell populations that exhibit a high functional avidity when responding to an infection or tumors. Furthermore, we discuss whether criteria based on which we evaluate an effective T-cell response to acute infections can also be applied to chronic infections such as HIV. Finally, we also focus on observations that high-avidity T-cells show higher signs of exhaustion and facilitate the emergence of virus escape variants. The review summarizes our current understanding of how this may occur as well as how T-cells of different functional avidity contribute to antiviral and anti-tumor immunity. Enhancing our knowledge in this field is relevant for tumor immunotherapy and vaccines design.http://dx.doi.org/10.1155/2012/153863 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Selena Viganò Daniel T. Utzschneider Matthieu Perreau Giuseppe Pantaleo Dietmar Zehn Alexandre Harari |
spellingShingle |
Selena Viganò Daniel T. Utzschneider Matthieu Perreau Giuseppe Pantaleo Dietmar Zehn Alexandre Harari Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells? Clinical and Developmental Immunology |
author_facet |
Selena Viganò Daniel T. Utzschneider Matthieu Perreau Giuseppe Pantaleo Dietmar Zehn Alexandre Harari |
author_sort |
Selena Viganò |
title |
Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells? |
title_short |
Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells? |
title_full |
Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells? |
title_fullStr |
Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells? |
title_full_unstemmed |
Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells? |
title_sort |
functional avidity: a measure to predict the efficacy of effector t cells? |
publisher |
Hindawi Limited |
series |
Clinical and Developmental Immunology |
issn |
1740-2522 1740-2530 |
publishDate |
2012-01-01 |
description |
The functional avidity is determined by exposing T-cell populations in vitro to different amounts of cognate antigen. T-cells with high functional avidity respond to low antigen doses. This in vitro measure is thought to correlate well with the in vivo effector capacity of T-cells. We here present the multifaceted factors determining and influencing the functional avidity of T-cells. We outline how changes in the functional avidity can occur over the course of an infection. This process, known as avidity maturation, can occur despite the fact that T-cells express a fixed TCR. Furthermore, examples are provided illustrating the importance of generating T-cell populations that exhibit a high functional avidity when responding to an infection or tumors. Furthermore, we discuss whether criteria based on which we evaluate an effective T-cell response to acute infections can also be applied to chronic infections such as HIV. Finally, we also focus on observations that high-avidity T-cells show higher signs of exhaustion and facilitate the emergence of virus escape variants. The review summarizes our current understanding of how this may occur as well as how T-cells of different functional avidity contribute to antiviral and anti-tumor immunity. Enhancing our knowledge in this field is relevant for tumor immunotherapy and vaccines design. |
url |
http://dx.doi.org/10.1155/2012/153863 |
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