Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function

Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function

Protective antibodies in Plasmodium falciparum malaria are only acquired after years of repeated infections. Chronic malaria exposure is associated with a large increase in atypical memory B cells (MBCs) that resemble B cells expanded in a variety of persistent viral infections. Understanding the fu...

Full description

Bibliographic Details
Main Authors: Silvia Portugal, Christopher M Tipton, Haewon Sohn, Younoussou Kone, Jing Wang, Shanping Li, Jeff Skinner, Kimmo Virtaneva, Daniel E Sturdevant, Stephen F Porcella, Ogobara K Doumbo, Safiatou Doumbo, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Inaki Sanz, Susan K Pierce, Peter D Crompton
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-05-01
Series:eLife
Subjects:
atypical memory B cell
Plasmodium falciparum
malaria
Online Access:https://elifesciences.org/articles/07218

Internet

https://elifesciences.org/articles/07218

Similar Items