Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport

Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport

The epithelial anion transporter SLC26A9 contributes to airway surface hydration and gastric acid production. Colocalizing with CFTR, SLC26A9 has been proposed as a target for the treatment of cystic fibrosis. To provide molecular details of its transport mechanism, we present cryo-EM structures and...

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Bibliographic Details
Main Authors: Justin D Walter, Marta Sawicka, Raimund Dutzler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
chloride transport
alternate access
patch clamp
cryo-EM
Online Access:https://elifesciences.org/articles/46986

Internet

https://elifesciences.org/articles/46986

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