Association of genetic variants in the promoter region of genes encoding p22phox (<it>CYBA</it>) and glutamate cysteine ligase catalytic subunit (<it>GCLC</it>) and renal disease in patients with type 1 diabetes mellitus

Association of genetic variants in the promoter region of genes encoding p22phox (<it>CYBA</it>) and glutamate cysteine ligase catalytic subunit (<it>GCLC</it>) and renal disease in patients with type 1 diabetes mellitus

<p>Abstract</p> <p>Background</p> <p>Oxidative stress is recognized as a major pathogenic factor of cellular damage caused by hyperglycemia. NOX/NADPH oxidases generate reactive oxygen species and NOX1, NOX2 and NOX4 isoforms are expressed in kidney and require associat...

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Main Authors: Pavin Elizabeth J, Parisi Maria C, Canani Luis H, Azevedo Mirela J, Vendramini Márcio F, Dib Sérgio A, Queiroz Márcia, Nery Márcia, Fortes Maria A, Luna Ana M, Marques Tatiana, Monteiro Maria B, Vieira Suzana M, Giannella-Neto Daniel, Corrêa-Giannella Maria L
Format: Article
Language:English
Published: BMC 2011-09-01
Series:BMC Medical Genetics
Online Access:http://www.biomedcentral.com/1471-2350/12/129

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http://www.biomedcentral.com/1471-2350/12/129

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