Antiproliferative Activity and in Vivo Toxicity of Double-Point Modified Analogs of 1,25-Dihydroxyergocalciferol

Antiproliferative Activity and in Vivo Toxicity of Double-Point Modified Analogs of 1,25-Dihydroxyergocalciferol

Analogs of 1,25-dihydroxyergocalciferol, modified in the side-chain and in the A-ring, were tested for their antiproliferative activity against a series of human cancer cell lines in vitro and in vivo toxicity. The proliferation inhibition caused by the analogs was higher than that of the parent c...

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Bibliographic Details
Main Authors: Justyna Trynda, Eliza Turlej, Magdalena Milczarek, Anita Pietraszek, Michał Chodyński, Andrzej Kutner, Joanna Wietrzyk
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:International Journal of Molecular Sciences
Subjects:
calcitriol and analogs
1,25-dihydroxyergocalciferol analogs
human cancer cell lines
antiproliferative activity in vitro
CD11b and CD14 cell-surface markers
cytoplasmic vacuolization
cell cycle
VDR and MARRS mRNA expression
Online Access:http://www.mdpi.com/1422-0067/16/10/24873

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http://www.mdpi.com/1422-0067/16/10/24873

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