Cytosolic sensor STING in mucosal immunity: a master regulator of gut inflammation and carcinogenesis

Cytosolic sensor STING in mucosal immunity: a master regulator of gut inflammation and carcinogenesis

Abstract The stimulator of interferon genes (STING) connects microbial cytosolic sensing with host cell effector functions. STING signaling plays a central role in cyclic dinucleotides (CDNs) and DNA sensing to induce secretion of interferons and pro-inflammatory mediators. Although activated STING...

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Bibliographic Details
Main Authors: Qiongyuan Hu, Quan Zhou, Xuefeng Xia, Lihua Shao, Meng Wang, Xiaofeng Lu, Song Liu, Wenxian Guan
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
STING
Mucosal barrier
Intestinal inflammation
Online Access:https://doi.org/10.1186/s13046-021-01850-9

Internet

https://doi.org/10.1186/s13046-021-01850-9

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