Decitabine and all-trans retinoic acid synergistically exhibit cytotoxicity against elderly AML patients via miR-34a/MYCN axis

Decitabine and all-trans retinoic acid synergistically exhibit cytotoxicity against elderly AML patients via miR-34a/MYCN axis

This study aimed to investigate the efficacy and mechanism of decitabine (DAC) and all-trans retinoic acid (ATRA) in elderly acute myeloid leukemia (AML) patients and cultured cells. Our clinical trial enrolled 36 elderly patients who were judged ineligible for conventional chemotherapy, receiving D...

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Bibliographic Details
Main Authors: Yang Cao, Yue Liu, Limei Shang, Wei Wei, Yangling Shen, Quan Gu, Xiaobao Xie, Weimin Dong, Yan Lin, Yanhua Yue, Fei Wang, Weiying Gu
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Decitabine
ATRA
miR-34a
MYCN
Acute myeloid leukemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220300688

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http://www.sciencedirect.com/science/article/pii/S0753332220300688

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