Decitabine and all-trans retinoic acid synergistically exhibit cytotoxicity against elderly AML patients via miR-34a/MYCN axis
This study aimed to investigate the efficacy and mechanism of decitabine (DAC) and all-trans retinoic acid (ATRA) in elderly acute myeloid leukemia (AML) patients and cultured cells. Our clinical trial enrolled 36 elderly patients who were judged ineligible for conventional chemotherapy, receiving D...
Main Authors: | Yang Cao, Yue Liu, Limei Shang, Wei Wei, Yangling Shen, Quan Gu, Xiaobao Xie, Weimin Dong, Yan Lin, Yanhua Yue, Fei Wang, Weiying Gu |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-05-01
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Series: | Biomedicine & Pharmacotherapy |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332220300688 |
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