Non-canonical amino acid labeling in proteomics and biotechnology

Non-canonical amino acid labeling in proteomics and biotechnology

Abstract Metabolic labeling of proteins with non-canonical amino acids (ncAAs) provides unique bioorthogonal chemical groups during de novo synthesis by taking advantage of both endogenous and heterologous protein synthesis machineries. Labeled proteins can then be selectively conjugated to fluoroph...

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Bibliographic Details
Main Authors: Aya M. Saleh, Kristen M. Wilding, Sarah Calve, Bradley C. Bundy, Tamara L. Kinzer-Ursem
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Biological Engineering
Subjects:
Metabolic labeling
Bioorthogonal chemistry
Residue-specific labeling
Site-specific labeling
Proteomics
Biotechnology
Online Access:http://link.springer.com/article/10.1186/s13036-019-0166-3

Internet

http://link.springer.com/article/10.1186/s13036-019-0166-3

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