Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of <i>Micrurus fulvius</i> (Eastern Coral Snake) Venom

Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of <i>Micrurus fulvius</i> (Eastern Coral Snake) Venom

There is a clear, unmet need for effective, lightweight, shelf-stable and economical snakebite envenoming therapies that can be given rapidly after the time of a snake&#8217;s bite and as adjuncts to antivenom therapies in the hospital setting. The sPLA2 inhibitor, LY315920, and its orally bioav...

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Bibliographic Details
Main Authors: Matthew R. Lewin, Lyndi L. Gilliam, John Gilliam, Stephen P. Samuel, Tommaso C. Bulfone, Philip E. Bickler, José María Gutiérrez
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Toxins
Subjects:
snakebite
envenoming
antidote
inhibitor
coral snake
<i>Micrurus fulvius</i>
PLA2
phospholipase A2
neurotoxicity
antivenom
Online Access:https://www.mdpi.com/2072-6651/10/11/479

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https://www.mdpi.com/2072-6651/10/11/479

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