Dose optimization of early high-dose valproic acid for neuroprotection in a swine cardiac arrest model

Dose optimization of early high-dose valproic acid for neuroprotection in a swine cardiac arrest model

Aim: High-dose valproic acid (VPA) improves the survival and neurologic outcomes after asphyxial cardiac arrest (CA) in rats. We characterized the pharmacokinetics, pharmacodynamics, and safety of high-dose VPA in a swine CA model to advance clinical translation. Methods: After 8 ​min of untreated v...

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Bibliographic Details
Main Authors: Cindy H. Hsu, Mohamad H. Tiba, Brendan M. McCracken, Carmen I. Colmenero, Zachary Pickell, Danielle C. Leander, Anne M. Weitzel, Sarita Raghunayakula, Jinhui Liao, Tulasi Jinka, Brandon C. Cummings, Manjunath P. Pai, Hasan B. Alam, Kevin R. Ward, Thomas H. Sanderson, Robert W. Neumar
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Resuscitation Plus
Subjects:
Cardiac arrest
Swine model
Valproic acid
Histone acetylation
Pharmacokinetic
Pharmacodynamics biomarker
Online Access:http://www.sciencedirect.com/science/article/pii/S2666520420300072

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http://www.sciencedirect.com/science/article/pii/S2666520420300072

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