Berberine Induces hERG Channel Deficiency through Trafficking Inhibition

Berberine Induces hERG Channel Deficiency through Trafficking Inhibition

Aims: The human ether-a-go-go-related gene (hERG) encodes the α subunit of the IKr, which plays an essential role in repolarization of action potentials. hERG channels are targeted by various pro-arrhythmic drugs. Berberine (BBR) was previously found to acutely inhibit hERG currents and prolong acti...

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Bibliographic Details
Main Authors: Kaiping Zhang, Duo Zhi, Ting Huang, Yan Gong, Meng Yan, Chen Liu, Ting Wei, Zengxiang Dong, Baoxin Li, Baofeng Yang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Berberine
hERG
Arrhythmia
Long QT Syndrome
Endoplasmic reticulum stress response
Unfolded protein response
Online Access:http://www.karger.com/Article/FullText/363034

Internet

http://www.karger.com/Article/FullText/363034

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