Hippocampal PPARα Plays a Role in the Pharmacological Mechanism of Vortioxetine, a Multimodal-Acting Antidepressant

Hippocampal PPARα Plays a Role in the Pharmacological Mechanism of Vortioxetine, a Multimodal-Acting Antidepressant

As a well-known multimodal-acting antidepressant, vortioxetine is thought to aim at several serotonin (5-HT) receptors and the 5-HT transporter. However, recently more and more proteins besides 5-HT are being reported to participate in the antidepressant mechanism of vortioxetine. As a widely known...

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Bibliographic Details
Main Authors: Yuan Wang, Jiang-Hong Gu, Ling Liu, Yue Liu, Wen-Qian Tang, Chun-Hui Ji, Wei Guan, Xin-Yi Zhao, Ying-Fang Sun, Da-Wei Xu, Bo Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
chronic unpredictable mild stress
chronic social defeat stress
depression
peroxisome proliferator activated receptor α
vortioxetine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.673221/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.673221/full

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