The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog

The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog

Nanog regulates embryonic stem cell (ESC) pluripotency but what controls Nanog protein stability is unclear. Here, the authors show that in mouse ESCs, Nanog protein is ubiquitinated and stabilized by the deubiquitinase USP21, which in turn is regulated by extrinsic signals, STAT3 and ERK.

Bibliographic Details
Main Authors: Jiali Jin, Jian Liu, Cong Chen, Zhenping Liu, Cong Jiang, Hongshang Chu, Weijuan Pan, Xinbo Wang, Lingqiang Zhang, Bin Li, Cizhong Jiang, Xin Ge, Xin Xie, Ping Wang
Format: Article
Language:English
Published: Nature Publishing Group 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13594

Internet

https://doi.org/10.1038/ncomms13594

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