Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis

Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis

There are two major pathways of bile acid synthesis: the “neutral” pathway, initiated by highly regulated microsomal cholesterol 7α-hydroxylase (CYP7A1), and an “alternative” pathway, initiated by mitochondrial sterol 27-hydroxylase (CYP27A1). In hepatocyte cultures, overexpression of CYP7A1 increas...

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Bibliographic Details
Main Authors: Shunlin Ren, Phillip Hylemon, Dalila Marques, Elizabeth Hall, Kaye Redford, Gregorio Gil, William M. Pandak
Format: Article
Language:English
Published: Elsevier 2004-11-01
Series:Journal of Lipid Research
Subjects:
metabolism
sterol carrier protein-2
MLN64
sterol 27-hydroxylase
cholesterol 7α-hydroxylase
steroidogenic acute regulatory protein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520341432

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http://www.sciencedirect.com/science/article/pii/S0022227520341432

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