Benzo(a)pyrene Enhanced Dermatophagoides Group 1 (Der f 1)-Induced TGFβ1 Signaling Activation Through the Aryl Hydrocarbon Receptor–RhoA Axis in Asthma

Benzo(a)pyrene Enhanced Dermatophagoides Group 1 (Der f 1)-Induced TGFβ1 Signaling Activation Through the Aryl Hydrocarbon Receptor–RhoA Axis in Asthma

We have previously demonstrated that benzo(a)pyrene (BaP) co-exposure with dermatophagoides group 1 allergen (Der f 1) can potentiate Der f 1-induced airway inflammation. The underlying mechanism, however, remains undetermined. Here we investigated the molecular mechanisms underlying the potentiatio...

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Bibliographic Details
Main Authors: Eryi Wang, Wei Tu, Danh C. Do, Xiaojun Xiao, Shehar B. Bhatti, Liteng Yang, Xizhuo Sun, Damo Xu, Pingchang Yang, Shau-Ku Huang, Peisong Gao, Zhigang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
RhoA
TGFβ1
BaP (6-benzylaminopurine)
Der f 1
aryl hydrocarbon receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.643260/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.643260/full

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