Droplet digital PCR as an alternative to FISH for MYCN amplification detection in human neuroblastoma FFPE samples

Droplet digital PCR as an alternative to FISH for MYCN amplification detection in human neuroblastoma FFPE samples

Abstract Background MYCN amplification directly correlates with the clinical course of neuroblastoma and poor patient survival, and serves as the most critical negative prognostic marker. Although fluorescence in situ hybridization (FISH) remains the gold standard for clinical diagnosis of MYCN stat...

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Bibliographic Details
Main Authors: Dinesh Babu Somasundaram, Sheeja Aravindan, Zhongxin Yu, Muralidharan Jayaraman, Ngoc T. B. Tran, Shibo Li, Terence S. Herman, Natarajan Aravindan
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Cancer
Subjects:
Neuroblastoma
MYCN amplification
Immunohistochemistry
FISH
ddPCR
Online Access:http://link.springer.com/article/10.1186/s12885-019-5306-0

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http://link.springer.com/article/10.1186/s12885-019-5306-0

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