Structural insights into the molecular mechanisms of myasthenia gravis and their therapeutic implications

Structural insights into the molecular mechanisms of myasthenia gravis and their therapeutic implications

The nicotinic acetylcholine receptor (nAChR) is a major target of autoantibodies in myasthenia gravis (MG), an autoimmune disease that causes neuromuscular transmission dysfunction. Despite decades of research, the molecular mechanisms underlying MG have not been fully elucidated. Here, we present t...

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Bibliographic Details
Main Authors: Kaori Noridomi, Go Watanabe, Melissa N Hansen, Gye Won Han, Lin Chen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-04-01
Series:eLife
Subjects:
myasthenia gravis
nicotinic acetylcholine receptors
crystallography
autoantibodies
Pichia pastoris
Online Access:https://elifesciences.org/articles/23043

Internet

https://elifesciences.org/articles/23043

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