MPP+ Injection into Rat Substantia Nigra Causes Secondary Glial Activation but Not Cell Death in the Ipsilateral Striatum

MPP+ Injection into Rat Substantia Nigra Causes Secondary Glial Activation but Not Cell Death in the Ipsilateral Striatum

Injection of MPP+ into the substantia nigra causes extensive necrosis and anterograde degeneration of pars compacta dopaminergic neurons. We studied secondary effects in the ipsilateral striatum by examining dopaminergic terminals, signs of neuronal damage, and glial reactivity at 1, 2, 3, and 7 day...

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Bibliographic Details
Main Authors: Anna M. Canudas, Bibiana Friguls, Anna M. Planas, Cecı´lia Gabriel, Elena Escubedo, Jordi Camarasa, Antoni Camins, Mercè Pallàs
Format: Article
Language:English
Published: Elsevier 2000-08-01
Series:Neurobiology of Disease
Subjects:
reactive glia
[3H]PK 11195
binding
immunohistochemistry
rat
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996100903085

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http://www.sciencedirect.com/science/article/pii/S0969996100903085

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