Co-administration of fresh grape fruit juice (GFJ) and bergamottin prevented paracetamol induced hepatotoxicity after paracetamol overdose in rats

Co-administration of fresh grape fruit juice (GFJ) and bergamottin prevented paracetamol induced hepatotoxicity after paracetamol overdose in rats

The aim of this study was to evaluate small doses of known cytochrome P450 enzyme inhibitors, grapefruit juice (GFJ) and one of its components, bergamottin (BGT), for the prevention of paracetamol (PAR)-induced hepatotoxicity after overdose in rats. Six groups of 15 Sprague Dawley (SD) rats each wer...

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Bibliographic Details
Main Authors: Refuoe Baleni, Zanelle Bekker, Andrew Walubo, Jan B. Du Plessis
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Toxicology Reports
Subjects:
Paracetamol
Overdose
Grapefruit juice
Hepatotoxicity
Prevention
Bergamottin
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750015000566

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http://www.sciencedirect.com/science/article/pii/S2214750015000566

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