Novel Concept of CD4-Mediated Activation of Regulatory T Cells for the Treatment of Graft-Versus-Host Disease

Novel Concept of CD4-Mediated Activation of Regulatory T Cells for the Treatment of Graft-Versus-Host Disease

Allogeneic hematopoietic stem cell transplantation is the only curative treatment option for several hematological malignancies and immune deficiency syndromes. Nevertheless, the development of a graft-versus-host disease (GvHD) after transplantation is a high risk and a severe complication with hig...

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Bibliographic Details
Main Authors: Janine Schlöder, Carsten Berges, Andrea Tuettenberg, Helmut Jonuleit
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
regulatory T cell
graft-versus-host disease
cellular therapy
tolerance
CD4 stimulation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01495/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01495/full

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