Interleukin-1β Promotes Epithelial-Derived Alveolar Elastogenesis via αvβ6 Integrin-Dependent TGF-β Activation

Interleukin-1β Promotes Epithelial-Derived Alveolar Elastogenesis via αvβ6 Integrin-Dependent TGF-β Activation

Background/Aims: IL-1β creates persistent pulmonary inflammation accompanied by elevated transforming growth factor β (TGF-β levels and is associated with abnormal elastogenesis, which is observed in bronchopulmonary dysplasia (BPD). Although progress has been made in this field, the mechanisms unde...

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Bibliographic Details
Main Authors: Jiarong Wang, Lei Bao, Benli Yu, Zhaoyun Liu, Wenli Han, Chun Deng, Chunbao Guo
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Bronchopulmonary dysplasia
IL-1β
Elastin
EMT αv&#03B2;6
Online Access:http://www.karger.com/Article/FullText/430185

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http://www.karger.com/Article/FullText/430185

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