Nitric oxide as a source for bacterial triazole biosynthesis

How nature creates 1,2,3-triazole ring is a relevant question to N-N bond biosynthesis. Here, the authors report the biosynthetic route to the triazole-bearing antimetabolite 8-azaguanine and reveal that this can be assembled through an enzymatic and non-enzymatic cascade, in which nitric oxide is u...

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Bibliographic Details
Main Authors: Guiyun Zhao, Yuan-Yang Guo, Shunyu Yao, Xinjie Shi, Longxian Lv, Yi-Ling Du
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15420-8