Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall Survival

Low Soluble Programmed Cell Death Protein 1 Levels After Allogeneic Stem Cell Transplantation Predict Moderate or Severe Chronic GvHD and Inferior Overall Survival

Programmed cell death protein-1 (PD-1) is an inhibitory co-receptor required for regulating immune responsiveness and maintaining immune homeostasis. As PD-1 can be released as bioactive soluble molecule, we investigated the clinical significance of soluble PD-1 (sPD-1) after allogeneic hematopoieti...

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Bibliographic Details
Main Authors: Lambros Kordelas, Ulrike Buttkereit, Falko M. Heinemann, Peter A. Horn, Bernd Giebel, Dietrich W. Beelen, H. Christian Reinhardt, Vera Rebmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
allogeneic hematopoietic stem cell transplantation
graft-versus-host disease
PD-1
soluble PD-1
immune checkpoint
inhibitory co-receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.694843/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.694843/full

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