Rapid progression to AML in a patient with germline GATA2 mutation and acquired NRAS Q61K mutation

Rapid progression to AML in a patient with germline GATA2 mutation and acquired NRAS Q61K mutation

GATA2 deficiency syndrome is caused by autosomal dominant, heterozygous germline mutations with widespread effects on immune, pulmonary and vascular systems. Patients commonly develop hematological abnormalities including bone marrow failure, myelodysplastic syndrome (MDS) and acute myeloid leukemia...

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Bibliographic Details
Main Authors: Lisa J. McReynolds, Yubo Zhang, Yanqin Yang, Jingrong Tang, Matthew Mulé, Amy P. Hsu, Danielle M. Townsley, Robert R. West, Jun Zhu, Dennis D. Hickstein, Steven M. Holland, Katherine R. Calvo, Christopher S. Hourigan
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Leukemia Research Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048919300093

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http://www.sciencedirect.com/science/article/pii/S2213048919300093

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