Leishmanicidal and Immunomodulatory Activities of the Palladacycle Complex DPPE 1.1, a Potential Candidate for Treatment of Cutaneous Leishmaniasis

Leishmanicidal and Immunomodulatory Activities of the Palladacycle Complex DPPE 1.1, a Potential Candidate for Treatment of Cutaneous Leishmaniasis

The present study focused on the activity of the palladacycle complex DPPE 1.1 on Leishmania (Leishmania) amazonensis. Promastigotes of L. (L.) amazonensis were destroyed in vitro by nanomolar concentrations of DPPE 1.1, whereas intracellular amastigotes were killed at drug concentrations fivefold l...

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Bibliographic Details
Main Authors: Isabela B. dos Santos, Danielle A. M. da Silva, Fabiana A. C. R. Paz, Daniel M. Garcia, Adriana K. Carmona, Daniela Teixeira, Ieda M. Longo-Maugéri, Simone Katz, Clara L. Barbiéri
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
cutaneous leishmaniasis
leishmaniasis treatment
Leishmania (Leishmania) amazonensis
palladacycle complex
immunomodulation
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01427/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01427/full

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