Blocking c-MET/ERBB1 Axis Prevents Brain Metastasis in ERBB2+ Breast Cancer

Blocking c-MET/ERBB1 Axis Prevents Brain Metastasis in ERBB2+ Breast Cancer

Brain metastasis (BrM) remains a significant cause of cancer-related mortality in epidermal growth factor receptor 2-positive (ERBB2<sup>+</sup>) breast cancer (BC) patients. We proposed here that a combination treatment of irreversible tyrosine kinase inhibitor neratinib (NER) and the c...

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Bibliographic Details
Main Authors: Shailendra K. Gautam, Ranjana K. Kanchan, Jawed A. Siddiqui, Shailendra K. Maurya, Sanchita Rauth, Naveenkumar Perumal, Pranita Atri, Ramakanth C. Venkata, Kavita Mallya, Sameer Mirza, Moorthy P. Ponnusamy, Vimla Band, Sidharth Mahapatra, Maneesh Jain, Surinder K. Batra, Mohd Wasim Nasser
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
breast cancer
brain metastasis
targeted therapy
c-MET/ERBB1 axis
combination therapy
orthotopic model
Online Access:https://www.mdpi.com/2072-6694/12/10/2838

Internet

https://www.mdpi.com/2072-6694/12/10/2838

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