An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers

An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers

Many of the molecular and pathological features associated with human Alzheimer disease (AD) are mirrored in the naturally occurring age-associated neuropathology in the canine species. In aged dogs with declining learned behavior and memory the severity of cognitive dysfunction parallels the progre...

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Bibliographic Details
Main Authors: Clare Rusbridge, Francisco J. Salguero, Monique Antoinette David, Kiterie M. E. Faller, Jose T. Bras, Rita J. Guerreiro, Angela C. Richard-Londt, Duncan Grainger, Elizabeth Head, Sebastian G. P. Brandner, Brian Summers, John Hardy, Mourad Tayebi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
canine cognitive dysfunction
Alzheimer
canine
Aβ oligomers
neuropathology
aggregation
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2018.00007/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2018.00007/full

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