The ruxolitinib effect: understanding how molecular pathogenesis and epigenetic dysregulation impact therapeutic efficacy in myeloproliferative neoplasms

The ruxolitinib effect: understanding how molecular pathogenesis and epigenetic dysregulation impact therapeutic efficacy in myeloproliferative neoplasms

Abstract The myeloproliferative neoplasms (MPN), polycythaemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) are linked by a propensity to thrombosis formation and a risk of leukaemic transformation. Activation of cytokine independent signalling through the JAK/STAT casca...

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Bibliographic Details
Main Authors: Graeme Greenfield, Suzanne McPherson, Ken Mills, Mary Frances McMullin
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Translational Medicine
Subjects:
Myeloproliferative neoplasms
Polycythaemia vera
Essential thrombocythemia
Primary myelofibrosis
Ruxolitinib
Epigenetics
Online Access:http://link.springer.com/article/10.1186/s12967-018-1729-7

Internet

http://link.springer.com/article/10.1186/s12967-018-1729-7

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