Necrosis Induction in Glioblastoma Cells Reveals a New “Bioswitch” Function for the MT1-MMP/G6PT Signaling Axis in proMMP-2 Activation versus Cell Death Decision

Necrosis Induction in Glioblastoma Cells Reveals a New “Bioswitch” Function for the MT1-MMP/G6PT Signaling Axis in proMMP-2 Activation versus Cell Death Decision

Cytoskeleton disorganization is an early step in the activation process of matrix metalloproteinase 2 (MMP-2) by membrane type 1 MMP (MTi-MMP) but is also associated with endoplasmic reticulum (ER) dysfunction and subsequent cell death. Given evidence that the ER-embedded glucose-6-phosphate transp...

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Bibliographic Details
Main Authors: Anissa Belkaid, Simon Fortier, Jian Cao, Borhane Annabi
Format: Article
Language:English
Published: Elsevier 2007-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Glioma
cytoskeleton
glucose-6-phosphate transporter
MT1MMP
necrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607801035

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http://www.sciencedirect.com/science/article/pii/S1476558607801035

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