Comparing efficacy and safety between Naldebain ® and intravenous patient-controlled analgesia with fentanyl for pain management post-laparotomy: study protocol for a randomized controlled, non-inferior trial

Abstract Background A long-acting prodrug of nalbuphine, nalbuphine sebacate, has been developed for meeting the unmet medical need of long-acting analgesics. Naldebain® (nalbuphine sebacate) has been developed as a new premedication for postoperative pain management. The primary objective of this s...

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Bibliographic Details
Main Authors: Hsiang-Lin Tsai, Tsung-Kun Chang, Wei-Chih Su, Yung-Sung Yeh, Ching-Wen Huang, Cheng-Jen Ma, Jaw-Yuan Wang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Trials
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13063-019-3260-4