NLRP3 inhibition attenuates early brain injury and delayed cerebral vasospasm after subarachnoid hemorrhage

NLRP3 inhibition attenuates early brain injury and delayed cerebral vasospasm after subarachnoid hemorrhage

Abstract Background The NLRP3 inflammasome is a critical mediator of several vascular diseases through positive regulation of proinflammatory pathways. In this study, we defined the role of NLRP3 in both the acute and delayed phases following subarachnoid hemorrhage (SAH). SAH is associated with dev...

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Bibliographic Details
Main Authors: William S. Dodd, Imaray Noda, Melanie Martinez, Koji Hosaka, Brian L. Hoh
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Neuroinflammation
Subjects:
Subarachnoid hemorrhage
Microglia
NLRP3 inflammasome
Stroke
Inflammation
Online Access:https://doi.org/10.1186/s12974-021-02207-x

Internet

https://doi.org/10.1186/s12974-021-02207-x

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