Restoration of Decreased T Helper 1 and CD8+ T Cell Subsets Is Associated With Regression of Lymphoproliferative Disorders Developed During Methotrexate Treatment

Restoration of Decreased T Helper 1 and CD8+ T Cell Subsets Is Associated With Regression of Lymphoproliferative Disorders Developed During Methotrexate Treatment

BackgroundLymphoproliferative disorder (LPD), including malignant lymphoma, is a relatively rare but life-threatening complication in RA patients under methotrexate (MTX) therapy. Spontaneous regression of LPD after MTX withdrawal is regarded as a distinct characteristic in part of such LPDs.Objecti...

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Bibliographic Details
Main Authors: Shuntaro Saito, Katsuya Suzuki, Keiko Yoshimoto, Yuko Kaneko, Kunihiro Yamaoka, Takayuki Shimizu, Takehiko Mori, Shinichiro Okamoto, Kaori Kameyama, Koichi Amano, Jun-ichi Tamaru, Michihide Tokuhira, Tsutomu Takeuchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
lymphoproliferative disorder
malignant lymphoma
regression
methotrexate
T cell subset
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00621/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00621/full

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