New mtDNA Association Model, MutPred Variant Load, Suggests Individuals With Multiple Mildly Deleterious mtDNA Variants Are More Likely to Suffer From Atherosclerosis

New mtDNA Association Model, MutPred Variant Load, Suggests Individuals With Multiple Mildly Deleterious mtDNA Variants Are More Likely to Suffer From Atherosclerosis

The etiology of common complex diseases is multifactorial, involving both genetic, and environmental factors. A role for mitochondrial dysfunction and mitochondrial DNA (mtDNA) variation has been suggested in the pathogenesis of common complex traits. The aim of this study was to investigate a poten...

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Bibliographic Details
Main Authors: Agnieszka Piotrowska-Nowak, Joanna L. Elson, Agnieszka Sobczyk-Kopciol, Aleksandra Piwonska, Aleksandra Puch-Walczak, Wojciech Drygas, Rafal Ploski, Ewa Bartnik, Katarzyna Tonska
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Genetics
Subjects:
mtDNA variation
MutPred
variant load
common complex diseases
atherosclerosis
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00702/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2018.00702/full

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