Distinct Immunophenotypes of T Cells in Bronchoalveolar Lavage Fluid From Leukemia Patients With Immune Checkpoint Inhibitors-Related Pulmonary Complications

Distinct Immunophenotypes of T Cells in Bronchoalveolar Lavage Fluid From Leukemia Patients With Immune Checkpoint Inhibitors-Related Pulmonary Complications

Patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) treated with immune checkpoint inhibitors (ICIs) are at risk of pneumonitis as well as pneumonia (combined henceforth as ICI-related pulmonary complications). Little is known about the cellular and molecular mechanisms und...

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Bibliographic Details
Main Authors: Sang T. Kim, Ajay Sheshadri, Vickie Shannon, Dimitrios P. Kontoyiannis, Hagop Kantarjian, Guillermo Garcia-Manero, Farhad Ravandi, Jin S. Im, Prajwal Boddu, Lara Bashoura, Diwakar D. Balachandran, Scott E. Evans, Saadia Faiz, Wilfredo Ruiz Vazquez, Margarita Divenko, Rohit Mathur, Samantha P. Tippen, Curtis Gumbs, Sattva S. Neelapu, Aung Naing, Linghua Wang, Adi Diab, Andrew Futreal, Roza Nurieva, Naval Daver
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
pneumonitis
Th17/Th1 cells
checkpoint inhibitor
acute myeloid leukemia
immune-related adverse event
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.590494/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.590494/full

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