Opposing regulation of PROX1 by interleukin-3 receptor and NOTCH directs differential host cell fate reprogramming by Kaposi sarcoma herpes virus.

Opposing regulation of PROX1 by interleukin-3 receptor and NOTCH directs differential host cell fate reprogramming by Kaposi sarcoma herpes virus.

Lymphatic endothelial cells (LECs) are differentiated from blood vascular endothelial cells (BECs) during embryogenesis and this physiological cell fate specification is controlled by PROX1, the master regulator for lymphatic development. When Kaposi sarcoma herpes virus (KSHV) infects host cells, i...

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Bibliographic Details
Main Authors: Jaehyuk Yoo, Ha Neul Lee, Inho Choi, Dongwon Choi, Hee Kyoung Chung, Kyu Eui Kim, Sunju Lee, Berenice Aguilar, Jinjoo Kang, Eunkyung Park, Yong Suk Lee, Yong-Sun Maeng, Nam Yoon Kim, Chester J Koh, Young-Kwon Hong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3375311?pdf=render

Internet

http://europepmc.org/articles/PMC3375311?pdf=render

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