Vaspin antagonizes high fat-induced bone loss in rats and promotes osteoblastic differentiation in primary rat osteoblasts through Smad-Runx2 signaling pathway

Abstract Background Visceral adipose tissue-derived serine protease inhibitor (vaspin), an adipose-derived hormone, exhibits various biological functions. Recently, studies showed that vaspin is closely related to bone metabolism. However, how vaspin influences bone formation and its underlying mech...

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Bibliographic Details
Main Authors: Hongwei Wang, Fulian Chen, Jiaxuan Li, Yan Wang, Chunyan Jiang, Mengqi Zhang, Jin Xu
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Nutrition & Metabolism
Subjects:
Online Access:https://doi.org/10.1186/s12986-020-0429-5