The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease

Chronic kidney disease (CKD) is associated with endothelial dysfunction and accelerated cardiovascular disease, which are largely driven by systemic oxidative stress and inflammation. Oxidative stress and inflammation in CKD are associated with and, in part, due to impaired activity of the cytoprot...

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Bibliographic Details
Main Authors: Mohammad A. Aminzadeh, Scott A. Reisman, Nosratola D. Vaziri, Stan Shelkovnikov, Seyed H. Farzaneh, Mahyar Khazaeli, Colin J. Meyer
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Redox Biology
Subjects:
Nrf2
Chronic kidney disease
Oxidative stress
Inflammation
Aorta
Synthetic triterpenoid
Bardoxolone methyl
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231713000761

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http://www.sciencedirect.com/science/article/pii/S2213231713000761

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