The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease
Chronic kidney disease (CKD) is associated with endothelial dysfunction and accelerated cardiovascular disease, which are largely driven by systemic oxidative stress and inflammation. Oxidative stress and inflammation in CKD are associated with and, in part, due to impaired activity of the cytoprot...
Main Authors: | Mohammad A. Aminzadeh, Scott A. Reisman, Nosratola D. Vaziri, Stan Shelkovnikov, Seyed H. Farzaneh, Mahyar Khazaeli, Colin J. Meyer |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2013-01-01
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Series: | Redox Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231713000761 |
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