TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family. Here we present the structure of the Caenorhabditis elegans TRIP13 ortholog PCH-2, revealing a new family of AAA+ ATPase p...

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Bibliographic Details
Main Authors: Qiaozhen Ye, Scott C Rosenberg, Arne Moeller, Jeffrey A Speir, Tiffany Y Su, Kevin D Corbett
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-04-01
Series:eLife
Subjects:
spindle assembly checkpoint
AAA+ ATPase
HORMA domain protein
Online Access:https://elifesciences.org/articles/07367

Internet

https://elifesciences.org/articles/07367

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