Whole-exome sequencing identified a novel mutation of MLH1 in an extended family with lynch syndrome

Whole-exome sequencing identified a novel mutation of MLH1 in an extended family with lynch syndrome

Hereditary nonpolyposis colorectal cancer or Lynch syndrome is autosomal dominant cancer predisposition syndrome characterized by early onset of colorectal cancer and neoplasia in other organs. This condition typically caused by germline mutations in the mismatch repair genes MLH1, MSH2, MSH6, and P...

Full description

Bibliographic Details
Main Authors: Hamid Ghaedi, Samira Molaei Ramsheh, Maryam Erfanian Omidvar, Afsaneh Labbaf, Elham Alehabib, Sanaz Akbari, Fatemeh Pourfatemi, Hossein Darvish
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Genes and Diseases
Subjects:
Colorectal cancer
Lung cancer
Mismatch repair
MLH1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304219300558

Internet

http://www.sciencedirect.com/science/article/pii/S2352304219300558

Similar Items