Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production

Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production

The authors use accelerated protons on photosensitizers (PS, conventionally excited by light), to generate fluorescence and singlet oxygen which can enhance the efficacy of proton therapy. A pilot study on glioblastoma cells confirms differential cell death upon irradiation in the presence of PS.

Bibliographic Details
Main Authors: M. Grigalavicius, M. Mastrangelopoulou, K. Berg, D. Arous, M. Ménard, T. Raabe-Henriksen, E. Brondz, S. Siem, A. Görgen, N. F. J. Edin, E. Malinen, T. A. Theodossiou
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12042-7

Internet

https://doi.org/10.1038/s41467-019-12042-7

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