Anti-parasitic effect of vitamin C alone and in combination with benznidazole against Trypanosoma cruzi.
BACKGROUND:Drugs currently used for the treatment of Chagas' disease, nifurtimox and benznidazole, have a limited effectiveness and toxic side effects. With the aim of finding new therapeutic approaches, in vitro and in vivo anti-Trypanosoma cruzi activity of vitamin C alone and combined with b...
Main Authors: | Vanesa Puente, Agostina Demaria, Fernanda M Frank, Alcira Batlle, Maria Elisa Lombardo |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-09-01
|
Series: | PLoS Neglected Tropical Diseases |
Online Access: | http://europepmc.org/articles/PMC6169970?pdf=render |
Similar Items
-
A quinoxaline derivative as a potent chemotherapeutic agent, alone or in combination with benznidazole, against Trypanosoma cruzi.
by: Jean Henrique da Silva Rodrigues, et al.
Published: (2014-01-01) -
Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole
by: Jair Téllez, et al.
Published: (2019-05-01) -
Mode of Action of the Sesquiterpene Lactones Psilostachyin and Psilostachyin C on Trypanosoma cruzi.
by: Valeria P Sülsen, et al.
Published: (2016-01-01) -
Essential oils from Syzygium aromaticum and Zingiber officinale, administered alone or in combination with benznidazole, reduce the parasite load in mice orally inoculated with Trypanosoma cruzi II
by: Marcella Paula Mansano Sarto, et al.
Published: (2021-02-01) -
Evaluation of in vitro anti-Trypanosoma cruzi activity of medications benznidazole, amiodarone hydrochloride, and their combination
by: Angela Maria Lourenço, et al.