Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning
Oligodendrocyte differentiation is known to depend on transcription factors Sox10, Nkx2.2, and Olig2. Here, the authors show that Nfat/calcineurin signaling contributes to oligodendrocyte differentiation by relieving mutual repression of Nkx2.2 and Olig2.
Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-03336-3 |