αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells
Integrins can regulate antigen-specific and innate immune receptor signalling, thereby affecting immune cell function. Here the authors show that avß3 integrin controls Toll-like receptor (TLR) signalling by regulating its trafficking to limit TLR-mediated B-cell proliferation and antibody productio...
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Bibliographic Details
Main Authors: |
Mridu Acharya,
Anna Sokolovska,
Jenny M. Tam,
Kara L. Conway,
Caroline Stefani,
Fiona Raso,
Subhankar Mukhopadhyay,
Marianela Feliu,
Elahna Paul,
John Savill,
Richard O. Hynes,
Ramnik J. Xavier,
Jatin M. Vyas,
Lynda M. Stuart,
Adam Lacy-Hulbert |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2016-03-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms10917
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