MCC950, a Selective Inhibitor of NLRP3 Inflammasome, Reduces the Inflammatory Response and Improves Neurological Outcomes in Mice Model of Spinal Cord Injury

MCC950, a Selective Inhibitor of NLRP3 Inflammasome, Reduces the Inflammatory Response and Improves Neurological Outcomes in Mice Model of Spinal Cord Injury

Spinal cord injury (SCI) is a serious condition that affects bodily function; however, there is no effective therapy in clinical practice. MCC950, a selective NOD-like receptor protein-3 (NLRP3) inflammasome inhibitor, has been reported to alleviate canonical and non-canonical NLRP3 inflammasome act...

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Bibliographic Details
Main Authors: Jianhang Jiao, Guanjie Zhao, Yang Wang, Pengfei Ren, Minfei Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
spinal cord injury
MCC950
NLRP3
functional recovery
inflammatory response
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00037/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.00037/full

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